Document Type

Article

Keywords

3,6-dichloro-8-nitroquinoline, 3,6-dibromo-8-nitroquinoline, 8-amino-3,6-dichloroquinoline, 8-amino-3,6-dibromoquinoline, 3,6-dichloro-8-quinolinol, 3,6-dibromo-8-quinolinol, 1H NMR spectra

Disciplines

Biochemistry

Abstract

3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct halogenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via a Skraup reaction. The nitro group was reduced to amino and the amine was hydrolyzed to the phenol in 70% sulfuric acid at 220 °C. The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, against Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the most fungitoxic analogue of this class of compounds observed to date

Article Number

1058

Publication Date

1994

Comments

Monatshefte für chemie 125:723-730. http://0-dx.doi.org.library.simmons.edu/10.1007/BF01277632

Included in

Biochemistry Commons

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